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EC number: 218-235-4
CAS number: 2090-05-3
The authors include a calculation of the 1% dose related to the
saturation of the metabolic system at that concentration. They conclude
that no bioaccumulation will occur. In addition, theoretically the
conclusion was derived that the no effect level in this study is closed
to the maximum tolorated level for the test substance.
A feeding study was performed, in which 4 generations of rats received
the test substance (0.5% or 1%). The first generation was exposed for 8
weeks an then allowed to mate (1/1 for a period of 14 days). Mating was
repeated in week 48 to raise a second litter. Survival of the first and
second generation was measured. The third generation was terminated
after 16 weeks and examined histopathologically. In this generation
weights of brain, heart, liver, spleen, kidneys and testes were
determined. The fourth generation was terminated after weaning of the
pups. Body weights were determined in week 4, 8 and 12 weeks of each
generation (week 12 males only). Feeding efficiency was measured in all
generations after 2,4, 6 and 8 weeks. Some reproduction parameters were
assessed: percentage of infertility, delayed sexual maturation, litter
size, total pups, surviving pups. These parameters were assessed for all
generations (summed) and forthe first two generations separately
No effects were noted after chronic dietary exposure of rats to 1% the
test substance in diet. Furthermore, no effects were observed on
fertility in four generations after chronic dietary exposure of rats to
1% the test substance in diet. No effects on reproduction were seen.
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