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EC number: 218-235-4
CAS number: 2090-05-3
Metal carboxylates are salts
consisting of metal cations and carboxylic acid anions. Based on the
solubility of calcium dibenzoate in water, a complete dissociation
resulting in calcium and benzoate ions may be assumed under
environmental conditions. The respective dissociation is in principle
reversible and the ratio of the salt /dissociated ions is dependent on
the metal-ligand dissociation constant of the salt, the composition of
the solution and its pH. However,
under environmental conditions, a reunion of the dissociated ions is
highly unlikely and it may reasonable be assumed that the respective
behaviour of the dissociated calcium cations and benzoate anions in the
environment determine the fate of calcium dibenzoate upon dissolution
with regard to (bio)degradation, bioaccumulation, partitioning resulting
in a different relative distribution in environmental compartments
(water, air, sediment and soil) and subsequently its (eco)toxicological
In the assessment of environmental
fate and toxicity of calcium dibenzoate, read-across to the assessment
entities soluble calcium substances and benzoic acid is applied since
the individual ions of calcium dibenzoate determine its environmental
fate and toxicity. Since calcium ions and dibenzoate ions behave
differently in the environment, in respect of their fate and toxicity, a
separate assessment of each assessment entity is performed. Please refer
to the data as submitted for each individual assessment entity.
In order to evaluate ecotoxicological
properties of the substance calcium dibenzoate, information on the
assessment entities calcium cation and benzoate anion were considered.
For a documentation and justification of that approach, please refer to
the separate document attached to section 13, namely Read Across
Assessment Report for calcium dibenzoate.
Aquatic toxicity studies with calcium
dibenzoate are not available, thus aquatic toxicity is addressed with
existing data on the dissociation products. Calcium
is naturally ubiquitous in the environment. As calcium is essential for
normal physiological functioning in species of all trophic levels, e.g.
as body structure-forming element of bones or exoskeletons or
elektrolyt in physiological liquids, it has a very low potential
for toxicity to freshwater and saltwater organisms and adverse
effects are lacking up to and including the respective OECD/EC
guidelines limit concentrations. The aquatic hazard
assessment is based on the most toxic moiety, i.e. the benzoate anion.
Existing aquatic toxicity data of benzoic acid are recalculated for
calcium dibenzoate based on a maximum benzoate content of 85.8 %.
Acute (short-term) toxicity: Reliable
acute aquatic toxicity data are available from guideline studies for
algae, daphnia, and fish. The lowest EC/LC50 values are 38.3 mg/L, >
115.6 mg/L, and 51.6 mg/L, respectively, and are well above the
classification cut-off value for acute (short-term) aquatic hazard
category 1. Therefore, calcium dibenzoate does not meet classification
criteria as short-term hazard to the aquatic environment under
Regulation (EC) No 1272/2008 and its subsequent adaptations.
Chronic (long-term) toxicity: Reliable
chronic aquatic toxicity data are available from guideline studies for
algae, daphnia, and fish. The lowest respective EC10/NOEC values are 3.9
mg/L, 28.9 mg/L, and 138.7 mg/L, respectively, and are well above the
classification cut-off values for long-term aquatic hazard category 1 -3
and criteria for classification in category 4 are also not met.
Therefore, calcium dibenzoate does not meet classification criteria as
long-term hazard to the aquatic environment under Regulation (EC) No
1272/2008 and its subsequent adaptations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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