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EC number: 281-092-1
CAS number: 83863-30-3
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cananga odorata, Annonaceae.
The mutagenic potential of Ylang Oil I was evaluated according to
guideline OECDTG 471. Ylang Oil I was tested in Salmonella typhimurium
tester strains TA1535, TA1537, TA98 and TA100 and Escherichia coli
tester strain WP2uvr at concentrations of 1.50, 5.00, 15.0, 50.0, 150,
500, 1500 and 5000 μg/plate in the absence and presence of S9-mix. Based
on the first mutation experiment, the following dose-range was selected
for the second mutation experiment with the Salmonella typhimurium
tester strains TA98 in the absence and presence of S9-mix: 15.0, 50.0,
150, 500, 1500, 3333 and 5000 μg/plate, and 15.0, 50.0, 150, 500, 1500
and 5000 μg/plate with all other conditions. Precipitation of Ylang Oil
I on the plates was observed at 5000 μg/plate with all conditions.
Cytotoxicity, as evidenced by a decrease in the number of revertants,
was not observed. Ylang Oil I did not induce a significant dose-related
increase in the number of revertant (His +) colonies in each of the four
tester strains (TA1535, TA1537, TA98 and TA100) and in the number of
revertant (Trp+) colonies in the tester strain WP2 uvrA, both in the
absence and presence of S9-metabolic activation. In this study,
acceptable responses were obtained for the negative and strainspecific
positive control items indicating that the test conditions were adequate
and that the metabolic activation system functioned properly. It is
concluded that Ylang Ylang I is not mutagenic and does not need to be
classified for genotoxicity in accordance with the criteria outlined in
Annex I of the CLP Regulation (1272/2008/EC).
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