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EC number: 281-092-1
CAS number: 83863-30-3
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cananga odorata, Annonaceae.
A Local Lymph Node Assay (LLNA) was performed according to the OECD
guideline 429 (2002). Four mice per group were treated with 0%, 0.5%,
1%, 2.5%, 5%, and 10% w/v Ylang Ylang Extra EO Comores in 1:3
ethanol:diethyl phthalate (vehicle) for three consecutive days, followed
by in vivo radiolabelling (by injection) and lymphocyte
proliferation analysis with the liquid scintillation counter. The number
of disintegrations per minute (dpm) was determined for each group for
the pooled lymph nodes. Treatment with Ylang Ylang Extra EO Comores did
induce significantly the lymph node proliferation in mice as compared to
controls at the highest dose tested. A higher than 3-fold increase in
lympocyte proliferation was found at the highest concentration tested
(10% w/v). The calculated EC3 was 6.8%. Under the conditions of this
assay, the test substance is needs to be classified as Skin Sensitiser
Category 1B in accordance with Annex I of the CLP Regulation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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