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EC number: 281-092-1 | CAS number: 83863-30-3 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cananga odorata, Annonaceae.
A Local Lymph Node Assay (LLNA) was performed according to the OECD guideline 429 (2002). Four mice per group were treated with 0%, 0.5%, 1%, 2.5%, 5%, and 10% w/v Ylang Ylang Extra EO Comores in 1:3 ethanol:diethyl phthalate (vehicle) for three consecutive days, followed by in vivo radiolabelling (by injection) and lymphocyte proliferation analysis with the liquid scintillation counter. The number of disintegrations per minute (dpm) was determined for each group for the pooled lymph nodes. Treatment with Ylang Ylang Extra EO Comores did induce significantly the lymph node proliferation in mice as compared to controls at the highest dose tested. A higher than 3-fold increase in lympocyte proliferation was found at the highest concentration tested (10% w/v). The calculated EC3 was 6.8%. Under the conditions of this assay, the test substance is needs to be classified as Skin Sensitiser Category 1B in accordance with Annex I of the CLP Regulation (1272/2008/EC).
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