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EC number: 695-097-5 | CAS number: 15789-90-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Standard method but limited documentation
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- rabbits tested, 5000 mg/kg bw, observation period 14d
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ionone, methyl-
- EC Number:
- 215-635-0
- EC Name:
- Ionone, methyl-
- Cas Number:
- 1335-46-2
- Molecular formula:
- C14H22O
- IUPAC Name:
- Ionone, methyl
- Details on test material:
- - Name of test material (as cited in study report): gamma-type methyl ionone
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 8
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs, mortality
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- 0/8 at 5000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this acute dermal toxicity test conducted in 8 rabbits, the LD50 was found to be above the highest tested dose of 5000mg/kg.
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