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EC number: 695-097-5
CAS number: 15789-90-9
Acute oral toxicity: - oral: LD50 cut-off >5000 mg/kg bw (rat, OECD 423), LD50 >5000 (rat) - dermal: LD50 >5000 mg/kg bw (rat)
number of animals
number of animals
H1 - H4
H0 - H2
H0 - D2
H1 - H3
D1 - D2
H0 - H1
S5: red smeared fur in the anogenital area
The oral acute toxicity of methylionone was tested in a study under GLP
performed according to OECD Guideline 423 (BASF, 1999). Three male and
three female Wistar rats were once administered by gavage with 2000
mg/kg bw in 5 ml/kg bw olive oil DAB 10. The following observation time
was 17 days for males and 14 days for females. Although signs of
toxicity were noted during the first days after application, the animals
appeared normal after five days. Since no mortality was observed, the LD
50 cut-off value was determined to be 5000 mg/kg bw.
In another study, ten rats (5 males, 5 females) were administered 5000
mg/kg bw orally (Givaudan, 1978). No deaths were observed within 14
days, thus the LD50 was determined to be >5000 mg/kg bw/day. The dose
for the LD50 study had previously been determined in a range-finder
test, in which 4 male and 4 female rats were adminstered 0.5, 1, 2, or 5
g/kg bw, no deaths were observed within 14 days (Givaudan, 1978).
In a third study, ten rats were administered orally with 5000 mg/kg bw
(Moreno, 1973). As no mortality occurred within the 14 day post dosing
observation time, the LD50 values was found to be >5000 mg/kg bw.
Although no further data were given, this study was evaluated reliable
as it is cited by the FFHPVC Terpene Consortium and the original data
are from highly experienced and respected toxicologists.
In an acute oral range-finding toxicity test, individually housed mice
aged 4-5 weeks were fasted for 4 hours and then orally intubated with 2,
5, or 10 ml/kg bw of undiluted test substance (2, 6
and 2 mice, respectively) (Quest, 1980). The mice were observed up to 7
days following treatment and dying mice were necropsied. All mice
surviving to the end of the observation period were weighed, killed and
examined post mortem. Due to observed mortality in the 5 and 10 ml/kg bw
groups (1/6 and 2/2 respectively), the LD50 was calculated to be >5 and
< 10 ml/kg bw and the methylionone was given a toxicity rating according
to Hodge and Sterner’s classification.
For evaluating the acute dermal toxicity, a concentration of 5000 mg/kg
bw was tested in eight rabbits (Moreno, 1973). Since no mortality was
observed during the 14 day observation period, the LD50 was determined
as >5000 mg/kg bw. Although the report was short, this study was
evaluated reliable as it is cited by the FFHPVC Terpene Consortium and
the original data are from highly experienced and respected
Due to the results from different studies including one performed
according to OECD Guideline 423, no classification is required.
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