(E)-3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one

Dermal absorption

Administrative data

Endpoint:

dermal absorption in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: no guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Ionone, methyl-

EC Number:

215-635-0

EC Name:

Ionone, methyl-

Cas Number:

1335-46-2

Molecular formula:

C14H22O

IUPAC Name:

Ionone, methyl

Details on test material:

Test material was a mixture of 14C labeled and non-radioactive material dissolved in ethanol at a concentration of 10%.

Radiolabelling:

yes

Remarks:

C14

Test animals

Species:

pig

Administration / exposure

Vehicle:

ethanol

Duration of exposure:

6 hours

Doses:

10% in ethanol

Results and discussion

Any other information on results incl. tables

600 µg/cm2: skin absorption

After 6 hours contact with pig skin approximately 2/3 of the test material applied was recovered with 358.72 ug/cm2 found on the skin surface, 24.92 ug/cm2 found in the horny layer of the skin, 16.32 ug/cm2 found in the remaining skin tissue layers, and 0.16 ug/cm2 found in the chamber liquid.

The unrecovered test material was presumably lost by evaporation from the skin surface.