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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: no guideline study
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test material

Constituent 1
Reference substance name:
Ionone, methyl-
EC Number:
215-635-0
EC Name:
Ionone, methyl-
Cas Number:
1335-46-2
Molecular formula:
C14H22O
IUPAC Name:
Ionone, methyl
Details on test material:
Test material was a mixture of 14C labeled and non-radioactive material dissolved in ethanol at a concentration of 10%.
Radiolabelling:
yes
Remarks:
C14

Test animals

Species:
pig

Administration / exposure

Vehicle:
ethanol
Duration of exposure:
6 hours
Doses:
10% in ethanol

Results and discussion

Any other information on results incl. tables

600 µg/cm2: skin absorption

After 6 hours contact with pig skin approximately 2/3 of the test material applied was recovered with 358.72 ug/cm2 found on the skin surface, 24.92 ug/cm2 found in the horny layer of the skin, 16.32 ug/cm2 found in the remaining skin tissue layers, and 0.16 ug/cm2 found in the chamber liquid.

The unrecovered test material was presumably lost by evaporation from the skin surface.

Applicant's summary and conclusion