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EC number: 695-097-5
CAS number: 15789-90-9
Based on a valid short-term fish study for the closely related substance
Isoraldeine 70, the fish 96 hour LC50 for
(E)-3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2 -one is
estimated to be 10.9 mg/L.The read-across is justified and considered
adequate for the purposes of classification and risk assessment.
A study to assess the short-term toxicity to fish is not available for
the registration substance. However, a valid short-term fish study does
exist for the related substance; Isoraldeine 70. Read-across from
this source substance is considered to give a reliable estimate of the
short-term toxicity of (E)-3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one
to fish and is justified based on the hypothesis that the target
substance and source substance will have similar ecotoxicological
properties as a result of structural similarity (both the target and
source substance consist of isomers), the same mode of action and
similar physicochemical properties. A detailed justification for the
proposed read-across in-line with the ECHA RAAF guidelines is provided
in the target endpoint record.
The study performed on Isoraldeine 70 (Study Report Number: B-161751,
Schlienger 1992) employed a static design. It is GLP compliant,
conducted to OECD guideline 203 and using test material (approximately
60% iso-alpha-methyl ionone, 91.4% total of all isomers) which is
representative of the source substance. The study design covered the
required exposure duration of 96 hours and included sufficient dose
levels to enable the relevant determination of potency. Analytical
confirmation was not performed and results were based on nominal
concentrations. However, give the stability of other related methyl
ionone source substances in both daphnia and algae studies (see IUCLID
endpoints 6.1.3. and 6.1.5 respectively), the study was considered
reliable with restrictions (reliability 2). The 96 hr EC50 was
determined to be 10.9 mg/L by plotting the log of the various test
concentrations against percentile mortality.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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