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Diss Factsheets
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EC number: 695-097-5 | CAS number: 15789-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/ study report which meets basic scientific principles
- Remarks:
- The detailed protocole description for the Open Application Test was inserted into the study report by mistake. The correct protocole, based on a concurrent study report, is attachede to this endpoint study record for information.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Covered patch test in Rabbit (see attached protocole)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ionone, methyl-
- EC Number:
- 215-635-0
- EC Name:
- Ionone, methyl-
- Cas Number:
- 1335-46-2
- Molecular formula:
- C14H22O
- IUPAC Name:
- Ionone, methyl
- Details on test material:
- - Sample No.: 11.549T1/1B
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 9 - 12 weeks
- Housing:individually
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.5 ml of neat substance
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4, 24, 48, and 72 hours
(grading for erythema, edema, cracking and scaling) - Number of animals:
- 8
- Details on study design:
- - standard controls: geraniol, cyclamen aldehyde, and diethyl phthalate
- statistics: Wilcoxon Matched-Pairs Signed Rank Test
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 177
- Reversibility:
- not fully reversible within: 72 h
Any other information on results incl. tables
Under the conditions of this study, the test substance caused moderate irritation to rabbit skin.
At 4 hours, produced marginal to distinct erythema and edema in most rabbits;
at 24 hours, the intensity of erythema and edema increased with 5/8 animals also showing marginal cracking;
at 48 hours, the intensity of erythema and edema stabilized and 6/8 animals had marginal to slight cracking with 1/8 animals having marginal scaling and
at 72 hours, 1/8 rabbits showed no erythema or edema; 7/8 had marginal to distinct erythema and edema; 7/8 had marginal to slight cracking and 5/8 had marginal scaling.
The overall irritation score was 177, mean score per site was 22.13, and mean score per site per day was 5.53.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Under the conditions of this study, the test substance caused only moderate irritation to rabbit skin.
However, due to the described irritation effects and choosing a conservative approach, methylionone is regarded as irritant to rabbit skin.
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