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EC number: 269-943-5
CAS number: 68391-31-1
The primary skin irritation potential of C
chloride) was investigat ed according to OECD test guideline no. 404.
The test item was applied by topical semi-occlusive application of 0.5 g
to the intact left flank of each of three young adult New Zealand White
rabbits. The duration of treatment was four hours. The scoring of skin
reactions was performed 1, 24, 48 and 72 hours, as weil as 7 and 10 days
after removal of the dressing.
The mean score was calculated across 3
scoring times (24, 48 and 72 hours after patch removal) for each animal
for erythema/eschar grades and for oedema grades, separately.
The mean erythema/eschar score and the mean
oedema score was 0.00 for all three animals.
The application of C 010
chloride) to the skin resulted in no signs of irritation. However slight
yellow staining of the treated skin was observed in two animals at the
1- and 24-hour reading and persisted in one animal up to the 7-day
examination. No corrosive effects were noted on the treated skin of any
animal at any of the measuring intervals and no clinical signs were
Thus, the test item did not induce
significant or irreversible damage to the skin.
Based on these results and according to the
CLP classification criteria: the test item C 010
(3-[(4,5-dihydro-3-methyl-5-oxo-1 -phenyl-1H- pyrazol- 4-yl)azo] -N,N,
N-trimethylanilinium chloride) is considered to be "not irritating" to
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