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EC number: 269-943-5
CAS number: 68391-31-1
of Clinical Signs of Toxicity and Mortality
System : Sprague Dawley Rat
Total Number of
Period of signs in days
From - to
No clinical signs observed
1 - 5
Day 0 - Day 14
6 - 10
of Evaluation of Dermal Reaction
No dermal reaction observed
Body Weight and Percent Body Weight Gain (g)
(mg/kg body weight)
Body weight Day 0
Body weight Day 7
% body weight gain
Body weight Day 14
day 7- 14
day 0- 14
of Gross Pathological Findings
Gross Pathological Findings
No abnormality detected
= Terminal Sacrifice
The reported study was designed and
conducted to determine the acute dermal toxicity profile of the given
test chemical as per OECD Guideline 402 (Acute Dermal Toxicity) in
Sprague Dawley rats.
The test item was applied to shorn
skin of 5 male and 5 female animals at 2000 mg/kg body weight.
Administration of the test item at 2000 mg/kg did not result in any skin
reaction at the site of application during the study period of 14 days.
Administration of the test item did not result in any signs of toxicity
and mortality during the study period of 14 days. Animals exhibited
normal body weight gain through the study period of 14 days. Gross
pathological examination did not reveal any abnormalities attributable
to the treatment.
Hence, it was concluded that the acute
dermal median lethal dose (LD50) of the given test chemical, when
administered to male and female Sprague Dawley rats was considered to be
>2000 mg/kg body weight. Thus by considering the CLP criteria for acute
toxicity rating for the chemicals, it infers that the given test
chemical does not exhibits acute toxicity by the dermal route. CLP
Classification: “Not classified”.
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