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EC number: 252-104-2
CAS number: 34590-94-8
Monomethyl ether of Dipropylene Glycol was evaluated for skin
penetration in rabbits. Male albinostrain rabbits, three to five months
of age and averaging 2.5 kg in weight, were immobilized during the
24-hour skin contact period. Thereafter, the VINYLITE sheeting used to
retain the dose in contact with the clipped skin of the trunk was
removed and the animals were caged for the remainder of the 14-day
observation period. The rabbits were procured locally and maintained
onrabbit station. The moving average method of calculating the LD50 was
Most deaths were delayed from three to four days after dosing. At
autopsy, gross observation disclosed some consolidation and congestion
of the lungs, dark mottled livers with prominent acini, and very pale
The LD50 was calculated to be 10.0 (6.8 to 14.8) ml/kg. as received.
Marked erythema of the skin was found upon removal of the impervious
plastic covering after the 24-hour contact. All survivors gained weight
during the two-week holding period. The test material was not classified
as toxic according to EU criteria as LD50 was greater than 2000 mg/kg bw.
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