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EC number: 252-104-2
CAS number: 34590-94-8
Male Fischer 344 rats were given a single
oral dose of approximately 8.7 mmole/kg of 14C DPGME. After dosing
expired air, excreta and tissues were analysed for 14C activity and
metabolites in urine were isolated and identified.
Approximately 60% of the 14C DPGME was
excreted in urine, while 27% was eliminated as 14CO2 within 48 hours
after an oral dose of 14C DPGME. Less than 3% of the dose was recovered
in feces, indicating that the test material was effectively absorbed.
DPGME was not completely hydrolysed to PGME and a higher percentage of
the radiolabeled DPGME was eliminated in the urine after dosing with
DPGME than occurred with PGME or PGMEA. DPGME, PGME, dipropylene glycol,
propylene glycol as well as sulfate and glucuronide conjugates of DPGME
were identifed in urine of animals. Therefore, DPGME is apparently
metabolized via the same routes to the same general types of metabolites
as those for PGME.
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