Methyl laurate

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: review article

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Review article.

Data source

Reference

Reference Type:

publication

Title:

Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission Flavouring Group Evaluation 2, Revision 1 (FGE.02Rev 1)

Author:

European Food Safety Authority

Year:

2008

Bibliographic source:

http://www.efsa.europa.eu/; The EFSA Journal (2008) 709-60

Report date:

2007

Materials and methods

Objective of study:

metabolism

Test material

Test material information

Constituent 1

Reference substance name:

Methyl laurate

EC Number:

203-911-3

EC Name:

Methyl laurate

Cas Number:

111-82-0

Molecular formula:

C13H26O2

IUPAC Name:

methyl dodecanoate

Details on test material:

- Name of test material (as cited in study report): Methyl dodecanoate
- CAS-No. of test material (as cited in study report): 111-82-0
- FL-No. of test material (as cited in study report):09.101

Results and discussion

Metabolite characterisation studies

Details on metabolites:

Data for short and medium length linear- and branched-chain alcohols, aldehydes and esters (and their alcohol and carboxylic acid moieties), included in the present Flavouring Group Evaluation and general information for this class of chemicals, indicate that they are rapidly absorbed from the gastrointestinal tract, metabolised and excreted. Also, in vitro hydrolysis data from studies with the supporting substances, as well as other closely related substances, indicate that the esters included in the present evaluation can be hydrolysed to yield the corresponding alcohols and carboxylic acids (Gangolli & Shilling, 1968; Grundschober, 1977; Leegwater & Straten, 1974a; Longland et al., 1977). General discussions on the biotransformation of linear aliphatic acids and aliphatic linear- and branched-chain alcohols and aldehydes, as well as hydrolysis of their esters, are provided in Annex III. In summary, it is anticipated that the 40 candidate esters [FL-no: 09.180, 09.307, 09.327, 09.331, 09.334, 09.358, 09.380, 09.390, 09.574, 09.579, 09.582, 09.583, 09.587 - 09.589, 09.592 - 09.594, 09.598, 09.599, 09.600, 09.602, 09.642, 09.651, 09.659 - 9.662, 09.664 - 09.666, 09.677, 09.681, 09.682, 09.700, 09.813, 09.814, 09.816, 09.819 and 09.820] will undergo hydrolysis to yield their corresponding aliphatic alcohols and linear carboxylic acids. The resulting aliphatic alcohols and linear carboxylic acids, as well as the six aliphatic alcohols [FL-no: 02.126, 02.154, 02.178, 02.180, 02.196 and 02.202] and one linear aliphatic aldehyde [FL-no: 05.152] are expected to be completely oxidised to carbon dioxide via the fatty acid pathway followed by the tricarboxylic acid cycle. The branched-chain alcohols can also be conjugated in part and excreted via the urine (see Annex III).