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EC number: 203-911-3
CAS number: 111-82-0
According to Article 13 of Regulation (EC) No. 1907/2006 "General
Requirements for Generation of Information on Intrinsic Properties of
substances", information on intrinsic properties of substances may be
generated by means other than tests e.g. from information from
structurally related substances (grouping or read-across), provided that
conditions set out in Annex XI are met.
Annex XI, "General rules for adaptation of this standard testing regime
set out in Annexes VII to X” states that “substances whose
physicochemical, toxicological and ecotoxicological properties are
likely to be similar or follow a regular pattern as a result of
structural similarity may be considered as a group, or ‘category’ of
substances…This avoids the need to test every substance for every
Since the group concept is applied to the members of the SCAE Me
category, data will be generated from a representative category member
to avoid unnecessary animal testing. Additionally, once the group
concept is applied, substances will be classified and labelled on this
Biodegradation in water: screening tests:
78% biodegradation in 28 days (OECD 301C)
No significant bioaccumulation in biota is expected for this substance
(see IUCLID section 5.3).
LC50 (96 h) > 0.52 mg/L for Oryzias latipes (OECD 203)
invertebrates: EC50 (48 h) = 0.255 mg/L for Daphnia magna (OECD
EC50 (72 h) = 0.324 mg/L for Pseudokirchneriella subcapitata (OECD
invertebrates: NOEC (21 d) = 0.0814 mg/L for Daphnia magna (OECD
NOEC (72 h) = 0.0396 mg/L for Pseudokirchneriella subcapitata (OECD
Classification justification according to CLP
Based on the data above, the acute aquatic toxicity EC50 values are < 1
mg/L for Daphnia magna and Pseudokirchneriella
subcapitata. Methyl laurate needs to be classified and labelled as acute
aquatic hazard Category 1 according to the
2nd ATP of Regulation (EC) No. 1272/2008 (CLP).
for acute aquatic toxicity: 1
for chronic aquatic toxicity: not to be assigned
Classification justification according to DSD
Based on the data above, methyl laurate (CAS No. 111-82-0) is considered
to be rapidly biodegradable and have low bioaccumulation potential.
Nevertheless, the acute aquatic toxicity tests available resulted in
EC50 values < 1 mg/L for Daphnia magna and Pseudokirchneriella
subcapitata. Thus, methyl laurate needs to be classified and
labelled as environmental hazard R50 according to the Directive
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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