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EC number: 203-911-3
CAS number: 111-82-0
According to Regulation (EC) No. 1907/2006, a substance must
fulfil all three criteria for persistence, bioaccumulation and toxicity
to be considered as PBT, as listed in part 1 of Annex XIII, and it must
fulfil the criteria for persistence and bioaccumulation stated in part 2
of Annex XIII to be considered vPvB.
Data for the definitive conclusion on the PBT or vPvB properties
according to the criteria set in Regulation (EC) No. 1907/2006, Annex
XIII, parts 1 and 2, are not available for all three criteria. Thus, the
screening criteria given in the ‘Guidance on information requirements
and chemical safety assessment - Chapter R.11: PBT assessment’ (ECHA,
2008) are used as surrogate information to decide whether the substance
may potentially fulfil the PBT or vPvB criteria.
Persistence (P) Assessment:
A valid screening criterion to evaluate persistence (P) is the
potential of a substance for ready biodegradability. Methyl laurate (CAS
No. 111-82-0) is readily biodegradable (78% biodegradation in 28 days).
Therefore, it is not expected to be persistent in the environment and it
does not meet the Persistent (P) or very Persistent (vP) criteria.
Bioaccumulation (B) Assessment:
An evaluation of the bioaccumulation potential of methyl laurate
(CAS No. 111-82-0) is presented in chapter 5.3 indicating that
bioaccumulation is expected to be low. Due to its ready
biodegradability, rapid metabolism in fish (see IUCLID section 5.3.1)
and the estimated BCF/BAF values, this substance is likely to show low
bioaccumulation potential. Based on the above information, methyl
laurate does not meet the Bioaccumulative (B) or very Bioaccumulative
Toxicity (T) Assessment:
The long-term no-observed effect
concentrations (NOEC values) reported in the tests conducted with
aquatic invertebrates and algae are higher than 0.01 mg/L, and the
substance is not classified as carcinogenic, mutagenic or toxic for
reproduction nor is there any evidence of chronic toxicity according to
the 2nd ATP of Regulation (EC) No. 1272/2008 (CLP) and Directive
67/548/EEC. Therefore, methyl laurate does not meet the T criterion
according to Regulation (EC) No. 1907/2006, Annex XIII.
In conclusion, methyl laurate (CAS No. 111-82-0) is considered not
to be PBT or vPvB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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