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EC number: 238-778-0
CAS number: 14726-36-4
The substance was studied in a GLP-compliant
mouse Local Lymph Node assay (LLNA) and was concluded that is not
sensitizing to skin.
Skin sensitizing potential of zinc
bis(dibenzyldithiocarbamate) (ZBEC) was studied in a GLP-compliant mouse
Local Lymph Node assay (LLNA) (Notox B.V., 2010c). Groups of 5 female
CDA/J mice were epidermally treated (25 μL/ear) with 10, 25 and 50% of
the test substance in DMSO. The control group was treated with the same
amount of vehicle only. Each animal was injected via the tail vein with
0.25 mL of sterile phosphate buffered saline (PBS) containing 20 μCi of
3H-methyl thymidine. After approximately five hours, all animals were
sacrificed and the draining lymph node of each ear was excised to
determine the number of desintegrations per minute (DPM) by
scintillation counter. The stimulation indices (SI; ratio DPM for test
group to DPM for control group) were determined for each dose level. The
SI were 0.7, 0.8 and 0.9 for 10, 25 and 50% test concentrations of the
substance in DMSO, respectively, suggesting that zinc
bis(dibenzyldithiocarbamate) is not sensitizing to skin.
Based on the stimulation indices < 3 for 50%
concentration of the test substance in DMSO in mouse LLNA,
classification of zinc bis(dibenzyldithiocarbamate) (ZBEC) as
sensitizing is not warranted in accordance with Directive 67/548/EEC and EU
Classification, Labelling and Packaging of Substances and Mixtures (CLP)
Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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