Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 238-778-0 | CAS number: 14726-36-4
Carcinogenicity
Administrative data
Description of key information
No data on carcinogenicity of zinc bis(dibenzyldithiocarbamate) (ZBEC) are available. In accordance with Column 2 of REACH Annex X, a carcinogenicity study may be proposed if the substance is classified as mutagen category 3 or there is evidence from the repeated dose studies that the substance is able to induce hyperplasia and/or pre-neoplastic lesions. Available data on ZBEC indicate that the substance is not genotoxic in vivo. In the 13-week oral study with no evidence of pre-neoplastic lesions or hyperplasia was found. Therefore, it is concluded that ZBEC is not carcinogenic and the performance of a carcinogenicity study is not indicated.
Key value for chemical safety assessment
Justification for classification or non-classification
Based on the lack of genotoxic potential of zinc bis(dibenzyldithiocarbamate) (ZBEC) and repeated dose toxicity data, classification of ZBEC for carcinogenicity is not warranted in accordance with Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
