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EC number: 238-778-0
CAS number: 14726-36-4
and eye irritating properties of zinc bis(dibenzyldithiocarbamate)
(ZBEC) were studied in two GLP-compliant guideline studies with rabbits.
No signs of skin irritation were noted at any time observation points in
the skin irritation study. Minor irritation of conjunctiva (redness,
chemosis and/or discharge) was noted in rabbits eyes 1 hour
post-instillation, which completely resolved within 48 hours. Based on
these results, the substance is considered to be not irritating to skin
Skin and eye irritating properties of zinc
bis(dibenzyldithiocarbamate) (ZBEC) were studied in two GLP-compliant
guideline studies with rabbits (Notox B.V., 2010a and 2010b). In the
skin irritation study, approximately 0.5 g of the test substance,
moistened with 0.7 mL of watery ethanol (50%) was applied to clipped
dorsal skin of 3 New Zealand White rabbits for 4 hours under
semi-occlusive conditions. Animals were observed for 72 hours. No signs
of irritation were noted at any time points, suggesting the that the
substance is not irritating to rabbit skin.
In the eye irritation study, ca. 40 mg (ca.
0.1 ml) of the test substance were instilled in one eye of 3 New Zealand
White rabbits. Immediately after the 24-hour observation, a solution of
2% fluorescein in water (adjusted to pH 7.0) was instilled into both
eyes of each animal to quantitatively determine corneal epithelial
damage. Minor irritation of the conjunctivae, which consisted of redness
chemosis and/or discharge (average scores 1) was observed at 1 hour
post-instillation. Redness persisted for 24 hours. The irritation
completely resolved within 48 hours. No iridial irritation or corneal
opacity was observed, and treatment of the eyes with 2% fluorescein 24
hours after test substance instillation revealed no corneal epithelial
damage. Based on the results of the study, ZBEC was considered to be not
irritating to rabbit eyes.
Based on the results of GLP-compliant
guideline studies on skin and eye irritation, classification of zinc
bis(dibenzyldithiocarbamate) (ZBEC) is not warranted in accordance with
Directive 67/548/EEC and EU
Classification, Labelling and Packaging of Substances and Mixtures (CLP)
Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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