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Ecotoxicological information

Short-term toxicity to fish

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Link to relevant study record(s)

Description of key information

Available information:
SAS-40
In a 96-h acute toxicity study, zebra fish (Danio rerio) were exposed to SAS-40 at nominal concentrations of 0 (control and solvent control), 1, 2.24, 5, 11.18 and 25 mg/L under static conditions. The LC50 based on the nominal concentration was 8.4 mg/L. The results have to be interpreted with caution since the LC50 is on the limit of water solubility of SAS-40.
SAS-296:
In a 96-h acute toxicity study, rainbow trout (Oncorhynchus mykiss) were exposed to SAS-296 at nominal concentrations of 0 (control and solvent control) and 0.56 mg/L under static conditions. The LD50 was greater than the solubility limit of 0.56 mg/l. Water concentrations were not measured and the poor solubility of test substance requires a careful interpretation of test results.
SAS-296:
The toxicity of 1,4-dimethyl-2-(1-phenylethyl) was determined in a freshwater fish, Orizias latipes according to OECD 203. A 96h LC50 of 0.31 mg/L was reported
QSARs - Data based on calculations using EPI Suite v4.10 (KOCWIN (Molecular Connectivity Method; worst case)/ ECOSAR Program v1.00. ECOSAR is a known and reliable calculation tool for this endpoint and therefore this estimation can be used in a weight-of-evidence approach. For PTE the calculated 96 h LC50 was 0.64 mg/L, for 11-DPE was 1.8 mg/L, for BT was 0.78 mg/L, for SAS-296 was 0.226 mg/L and for SAS-305 was 0.12 mg/L.

Key value for chemical safety assessment

LC50 for freshwater fish:
0.31 mg/L

Additional information

The key studies for the effect assessment are reliable with restrictions and were conducted according to an internationally accepted guideline. The lowest LC50 value is read across to 1,1 -DPE. No further testing is required.

For detailed read across rationale and justification see section 13, Read across document.