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EC number: 254-179-7
CAS number: 38888-98-1
Skin irritation:In an in-vitro skin irritation study according to OECD 439 (Human Skin Model Test) 1,1-DPE was found to be irritative to the human skin.Untreated DPE 75 (75% diphenyl ethane) was tested for oral and dermal toxicity in groups of 3 male rats. Skin irritation studies were performed with 3 New Zealand White rabbits in each case. A primary irritation index (PII) of 4 was obtained indicating that this material is a moderate skin irritant. Untreated DPE75 is moderately irritating to the skin which is probably caused by a defatting action. Eye irritation:In-vivo eye irritation studies were performed with 3 New Zealand White rabbits in each case. Untreated DPE 75 (75% diphenyl ethane) was placed into the eye of each rabbit by gently pulling the lower lid away from the eyeball to form a cup. Assessment of ocular irritation was made 1, 24, 48 and 72-hours after treatment using the Draize Scoring system. According to the CLP and DSD criteria this substance was not considered to be irritant to the eyes.
% Formazan production (Tissue 1)
% Formazan production (Tissue 2)
% Formazan production (Tissue 3)
% Formazan production Mean
Three tissues of the human skin mode! EpiDerm™were treated with
(phenylethyl)benzene for 60 minutes.
30 µL of the liquid test item (using a nylon mesh) were applied to
each tissue and spread to match the tissue size (0.63 cm2; as
indicated by supplier).
DPBS-buffer was used as negative control, 5% SDS-solution was used
as positive control.
After treatment with the negative control, the absorbance values
were within the required acceptability criterion of 1.0 < mean OD < 2.5.
The positive control showed clear irritating effects. Variation within
tissues was acceptable (<18 %).
No data gaps were identified. The available data are adequate for risk
assessment and classification and labelling purposes.
According to the CLP Regulation, the
substance is classified as:
Irritant, Category 2, based on Formazan production < 50% of the negative
Eye irritation: 1,1 -DPE is not classified
as eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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