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EC number: 254-179-7
CAS number: 38888-98-1
For category rationale and justification see attached category
documentation under section 13 "Assessment Reports".
A study was performed to assess the irritancy potential of the
test material to the skin of the New Zealand White rabbit. The method
used followed the recommendations of the OECD Guidelines for Testing of
Chemicals No. 404 "Acute Dermal Irritation/Corrosion" (adopted 17 July
1992) and Method B4 of Commission Directive 92/69/EEC (which constitutes
Annex V of Council Directive 67/548/EEC). A single 4-hour,
semi-occluded application of the test material to the intact skin of
three rabbits produced very slight to well-defined erythema and very
slight oedema. Other skin reactions noted were crust formation and
moderate desquamation. Slight desquamation was noted at all treated skin
sites at the 14-day observation. The test material produced a primary
irritation index of 2.3 and was classified as a moderate irritant to
rabbit skin according to the Draize classification scheme. No corrosive
effects were noted. The test material was also classified as irritant
according to EU labelling regulations.
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