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EC number: 254-179-7
CAS number: 38888-98-1
The Mass Median Aerodynamic Diameter (MMAD) and geometric standard
deviation (gsd) were determined twice. For the 5 mg/L exposure group,
the MMAD was 2.9 μm (gsd 1.9) and 2.6 μm (gsd 2.1). For the 1 mg/L
exposure group, the MMAD was 2.8 μm (gsd 2.1) and 2.9 μm (gsd 1.9).
Phenyl-tolyl-ethane was administered as an aerosol by inhalation for 4
hours to two groups of five male and five female Wistar rats each group.
Animals were subjected to daily observations and determination of body
weights on Days 1, 2, 8 and 15. Macroscopic examination was performed on
the day of death or after terminal sacrifice (Day 15).
At 5 mg/L, on the day following exposure (Day 2) three males and two
females were found dead and the remaining animals were sacrificed for
ethical reasons. At 1 mg/L, one female was sacrificed for ethical
reasons on Day 2. No further mortality occurred. At 5 mg/L, the animals
showed gasping and laboured respiration during exposure. After exposure,
hunched posture, lethargy, flat posture, laboured respiration,
piloerection, ptosis and/or moribund status were shown by the animals.
At 1 mg/L, no clinical signs were noted during exposure. After exposure,
the animals showed lethargy, hunched posture, piloerection and/or ptosis
between Days 1 and 4. In addition, the female sacrificed on Day 2 showed
uncoordinated movements, chromodacryorrhoea, hypothermia, shallow
respiration and a lean appearance. At 5 mg/L, body weights loss was
noted in the animals found dead or sacrificed on Day 2. At 1 mg/L,
overall body weight gain and body weight loss in males and females was
within the range expected for rats of this strain and age used in this
type of study. At 5 mg/L, macroscopic post mortem examination of the
animals that were found dead or sacrificed for ethical reasons during
the study revealed abnormalities of the lungs (many dark red foci),
stomach (black foci in the glandular mucosa), liver (pale discoloration)
and mandibular lymph nodes (dark red discoloration). At 1 mg/L, no
abnormalities were found at macroscopic post mortem examination of the
animals. The inhalatory LC50, 4h value of Phenyl-tolyl-ethane in Wistar
rats was established to be within the range of 1 – 5 mg/L.
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