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EC number: 217-461-0 | CAS number: 1860-26-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The substance is moderately biodegradable (not readily biodegradable).
Key value for chemical safety assessment
Additional information
Parent compound:
No reliable data are available for tris-2-ethylhexylamine (CAS 1860-26-0). Therefore, in order to assess the biodegradation potential of tris-2-ethylhexylamine (CAS 1860-26-0), a read across to the analogue substance di-(2-ethylhexyl)amine (CAS 106-20 -7) with structural similarity was performed. Experimental data are available from an enhanced ready biodegradability test according to OECD 301B, conducted with non-adapted, domestic activated sludge as inoculum (BASF SE, 2016). Elimination of the test item was determined to be 91% after 60 days of exposure, based on CO2 evolution. However, after 28 days, biodegradation was determined to be 69%, but the pass level of the 10-day window was slightly failed as biodegradation was approximately 58% at the end of the 10-day window.
In addition, the results from an enhanced ready biodegradability test according to OECD 301B, conducted with non-adapted, domestic activated sludge as inoculum are available (BASF SE, 2012). Elimination of the test item was determined to be 0.9% after 28 days based on CO2 evolution. Based on DOC removal, 83% of the substance was eliminated after 28 days, which is, however, interpreted to be likely due to adsorption to the sludge and/or test vessels. Additional experimental data are available from a CO2 evolution test conducted similar to OECD 301B (BASF AG, 1997; report no. 97/0028/22/1) with non-adapted, domestic activated sludge as inoculum. The substance was degraded to approximately 50% after 39 days of incubation. However, the plateau phase of the biodegradation curve was not reached after 39 days. The biodegradation curve still showed an upward trend indicating that the biodegradation of the molecule was not completed.
In addition to the read-across approach, the ready biodegradability was assessed using a QSAR model CATALOGIC Kinetic OECD 301C v.11.16. The substance was within the applicability domains of the model. The substance was predicted to be not readily biodegradable. Based on the estimated degree of degradation, moderate biodegradability is a realistic assumption.
- CATALOGIC Kinetic OECD 301C v.11.15: 7% in 28 d, not readily biodegradable
Metabolites:
CATALOGIC 301C v11.16 (OASIS Catalogic v5.14.1.5) predicted for the parent compound 33 metabolites, identifying 16 metabolites as relevant degradation products in terms of PBT/vPvB assessment, with an estimated quantity of ≥ 0.1% (for details see ‘Attached background material’ of the respective Endpoint Study Record).
Five of the relevant metabolites were calculated to be readily biodegradable (≥ 60% after 28 days, based on BOD). The other relevant metabolites were estimated to be not readily biodegradable (4 to 44% after 28 days, based on BOD). In conclusion, the majority of the predicted metabolites present in a concentration of ≥ 0.1% (equivalent to >=0.001 mol/mol parent) are estimated to be not readily biodegradable.
Table: QSAR prediction for CAS 1860-26-0 (Piperazine) using CATALOGIC 301C v11.16 (OASIS CATALOGIC v5.14.1.5; metabolites with a quantity > 0.001 mol/mol parent after 28 d are highlighted by grey background and bold type; metabolite no: according to (Q)SAR model Catalogic v11.16)
# | Metabolite | Smiles | Quantity | LogKow | BOD prediction | BCF including mitigating factors | PBT-Assessment |
parent | 1 | CCCCC(CC)CN(CC(CC)CCCC)CC(CC)CCCC | 0.701 | 10.1 | 7% | 6.9 | - |
1 | 26 | CCCCC(CC)CN(CC(CC)CCCC)CC(=O)CC | 0.056 | 7.0 | 4% | 5.4 | not listed |
2 | 33 | CCCCC(CC)CN(CC(CC)CCCC)CC(=O)CCCC | 0.054 | 7.9 | 4% | 5.8 | not listed |
3 | 16 | CCCCC(CC)CN / 2-ethylhexylamine / CAS 104-75-6 | 0.041 | 2.7 | 40% | 33.9 | not PBT/vPvB |
4 | 4 | CCCCC(CC)C(O)=O / 2-ethylhexanoic acid / CAS 149-57-5 | 0.031 | 3.0 | 77% | 5.5 | not PBT/vPvB |
5 | 25 | CCCCC(CC)CN(CC(CC)CCCC)CC(O)(CC)CC(O)=O | 0.031 | 3.2 | 14% | 8.7 | not listed |
6 | 32 | CCCCC(CC)CN(CC(CC)CCCC)CC(O)(CCCC)CC(O)=O | 0.031 | 4.2 | 15% | 20.4 | not listed |
7 | 5 | CCCC=C(CC)C(O)=O / 2-ethylhex-2-enoic acid / CAS 5309-52-4 | 0.027 | 2.9 | 67% | 13.5 | not listed |
8 | 6 | CCCC(O)C(CC)C(O)=O | 0.024 | 1.4 | 66% | 3.2 | not listed |
9 | 8 | CCCC(=O)C(CC)C(O)=O | 0.020 | 0.9 | 91% | 3.2 | not listed |
10 | 2 | CCCCC(CC)CNCC(CC)CCCC / Bis(2-ethylhexyl)amine / CAS 106-20-7 | 0.015 | 6.6 | 44% | 871 | not PBT/vPvB |
11 | 3 | CCCCC(CC)C=O / 2-ethylhexanal / CAS 123-05-7 | 0.010 | 2.7 | 78% | 3.8 | not listed |
12 | 27 | CCCCC(CC)CN(CC(CC)CCCCO)CC(=O)CC | 0.005 | 5.5 | 23% | 4.8 | not listed |
13 | 28 | CCCCC(CC)CN(CC(CCCC)CCO)CC(=O)CC | 0.005 | 5.5 | 13% | 4.8 | not listed |
14 | 35 | CCCCC(CC)CN(CC(CC)CCCCO)CC(=O)CCCC | 0.004 | 6.5 | 22% | 5.2 | not listed |
15 | 36 | CCCCC(CC)CN(CC(CCCC)CCO)CC(=O)CCCC | 0.004 | 6.5 | 13% | 5.2 | not listed |
16 | 34 | CCCCC(CC)CN(CC(CC)CCCC)CC(=O)CCCCO | 0.002 | 6.5 | 22% | 5.2 | not listed |
17 | 37 | CCCCC(CC)CN(CC(CC)CCCC)C(O)C(CC)CCCC | 1.17E-08 | 8.6 | 47% | n.a. | n.a. |
18 | 11 | CC(O)CC(O)=O | 0 | -0.5 | 100% | n.a. | n.a. |
19 | 12 | CC(=O)CC(O)=O | 0 | -1.0 | 100% | n.a. | n.a. |
20 | 10 | CC=CC(O)=O | 0 | 0.9 | 100% | n.a. | n.a. |
21 | 9 | CCCC(O)=O | 0 | 1.1 | 100% | n.a. | n.a. |
22 | 24 | CCCCC(CC)CN(CC(CC)CCCC)CC(CC)CC(O)=O | 0 | 4.7 | 16% | n.a. | n.a. |
23 | 30 | CCCCC(CC)CN(CC(CC)CCCC)CC(CCCC)CC=O | 0 | 8.6 | 17% | n.a. | n.a. |
24 | 20 | CCCCC(CC)CN(CC(CC)CCCC)CC(CC)CCCC(O)=O | 0 | 5.7 | 23% | n.a. | n.a. |
25 | 19 | CCCCC(CC)CN(CC(CC)CCCC)CC(CC)CCCC=O | 0 | 8.6 | 24% | n.a. | n.a. |
26 | 18 | CCCCC(CC)CN(CC(CC)CCCC)CC(CC)CCCCO | 0 | 8.7 | 24% | n.a. | n.a. |
27 | 29 | CCCCC(CC)CN(CC(CC)CCCC)CC(CCCC)CCO | 0 | 8.7 | 17% | n.a. | n.a. |
28 | 31 | CCCCC(CC)CN(CC(CC)CCCC)CC(CCCC)CC(O)=O | 0 | 5.7 | 16% | n.a. | n.a. |
29 | 22 | CCCCC(CC)CN(CC(CC)CCCC)CC(CC)CC(O)CC(O)=O | 0 | 4.2 | 22% | n.a. | n.a. |
30 | 23 | CCCCC(CC)CN(CC(CC)CCCC)CC(CC)CC(=O)CC(O)=O | 0 | 3.6 | 22% | n.a. | n.a. |
31 | 7 | CCCC(O)=C(CC)C(O)=O | 0 | 2.0 | 91% | n.a. | n.a. |
32 | 21 | CCCCC(CC)CN(CC(CC)CCCC)CC(CC)CC=CC(O)=O | 0 | 7.0 | 23% | n.a. | n.a. |
33 | 13 | CC(O)=O | 0 | 0.1 | 100% | n.a. | n.a. |
n.a.– not assessed. Metabolites with a quantity < 0.001 mol/mol parent after 28 d are not considered being relevant for the PBT/vPvB assessment and, therefore their PBT/vPvB status and BCF value were not assessed.
Conclusion: Based on the available experimental data from a read-across to a structurally similar substance bis(2-ethylhexyl) (CAS 106-20-7) along with the estimated data for tris-2-ethylhexylamine (1860-26-0) itself, it can be considered that the substance is moderately biodegradable (not readily biodegradable) and is not persistent.
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