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EC number: 217-461-0
CAS number: 1860-26-0
Skin: not irritating (rabbit, 1975, occlusive application for 1 min, 5
min, 15 min and 20 h)
Eyes: not irritating (rabbit, 1974, comparable to OECD TG 405)
Table 1: Mean erythema score after 24 and 48
h (72 h reading is missing)
Table 2: Mean edema score after 24 and 48h
(72 h reading is missing)
The original BASF grading was converted into
the numerical grading according the OECD Draize system.
Table 1: Eye irritation parameter observed
in two treated animals
The original BASF grading was
converted into the numerical grading according to the OECD Draize system.
a study according to an internal protocol undiluted test substance was
applied under occlusive conditions to the skin of rabbits for one
minute, 5 minutes, 15 minutes and 20 hours, respectively. Occlusive
exposure caused slight to moderate reddening of the dorsal rabbit skin
extending beyond the area of exposure. Mean erythema scores (24-48 h)
were 1.75 (1 min), 1.5 (5 min), 1.5 (15 min) and 2.5 (20 h). Mean edema
scores (24-48 h) were 0 (1 min), 0 (5 min), 0 (15 min) and 0.5 (20 h).
Since the readings after 72 h were missing from the raw data, only
readings after 24 and 48 h were taken into consideration for scoring.
the end of the observation period of 8 days erythema and edema had fully
reversed. The animals showed scale formation at all exposure times. In
case of the 20 h application scaling was
extending beyond the area of exposure.
application for 20h under occlusive dressing gives overpredictive
results as compared to the specifications of the OECD TG 404, only the
effects after 1, 5, and 15 min application were considered for
estimating the skin irritation potential of the substance. Taking all
the relevant data into account, the test substance is not considered
irritating to rabbit skin.
a study comparable to OECD TG 405 undiluted test substance was instilled
into one eye of two rabbits. The adjacent eyes were treated with saline
and served as control. The eyes were not washed out after 24 hours as
specified in OECD Guideline 405. Mean scores for cornea, iris,
conjunctivae and chemosis (24-48-72 hours) were 0, 0, 1, and 0,
respectively. All effects were fully reversible within 8 days.
the substance is not irritating to the eyes of rabbits.
respiratory irritation was reported in the studies performed. There is
some evidence from the described inhalation hazard test that the test
material vapours may be slightly irritating to the mucous membranes of
rats (1975; reliability 2). However, the observations do not indicate
available experimental test data are reliable and suitable for
classification purposes under Regulation 1272/2008,
as amended for the thirteenth time in Regulation (EU) No 2018/1480.
As a result the substance is not considered to be classified for
irritation under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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