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EC number: 217-461-0
CAS number: 1860-26-0
No chronic toxicity effect is expected for
aquatic invertebrates since the water solubility (< 0.002 mg/L) is below
any effect level (NOEC >= 10 mg/L).
For the assessment of the long-term
toxicity of 2-ethyl-N,N-bis(2-ethylhexyl)hexylamine (CAS 1860-26-0) to
aquatic invertebrates experimental data are available.
In the GLP key study conducted
according to OECD Guideline 211 no ecotoxicity effect was observed (21-d
NOEC >= 10 mg/L, nominal, BASF SE, 2014).
The test substance is poorly soluble
in water. Therefore, the test solutions were prepared following general
guidance provided in OECD 23 in order to generate a saturated solution
of the test substance in test medium. The volume of the test substance
required for preparation of the nominal concentration was calculated
from the density (d=0.8174 g/cm3). Information on the saturation
concentration cannot be provided as the available analytical method is
not sensitive enough to quantify the Substance at levels close to or
below the water solubility limit. An analytical method by LC/MS for the
determination of the test substance was developed at the Analytical
Chemistry Laboratory of Experimental Toxicology and Ecology of BASF SE,
Ludwigshafen, Germany. However, an analytical verification of the test
material concentration is not feasible as the limit of quantitation
(LOQ) is significantly higher than the water solubility of the
Substance. The LOQ for this method was approx. 0.3 mg/L and the water
solubility of the test substance is < 0.002 mg/L. No reliable method for
analyses in the required concentration range could be developed.
Therefore, concentration control
analysis was not performed. However, since all reasonable efforts were
taken to produce a saturated solution of the test substance in test
media, following the guidance in OECD 23, the test results should be
based on loading concentration. The daphnids were exposed to the entire
loaded mass of test substance over each renewal period.
A study on the stability of the
Substance in the test medium was also not performed due to the lack of a
reliable analytical method. With regard to the stability a decline in
the concentration could be possible by adsorption based on the high log
Kow. However, the Substance is not biodegradable and is not expected to
degrade by hydrolysis. The test solutions were replaced daily, which
should have been sufficient to achieve a relatively stable loading rate.
And therefore, it can be concluded
that the substance has no chronic effect is expected towards aquatic
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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