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EC number: 254-879-2
CAS number: 40306-75-0
The substance, 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid, do not have a bioaccumulation potential based on estiamtion results supported by the facts of physicochemical parameters and persistant nature of the substance.
Based on the weight of evidence for the
target substance 3-acetamido-5-amino-4-hydroxy
benzene sulphonic acid, it is evident that the substance do not have
bioaccumulative property and so low adsorption capacity. Thus indicting
less toxicokinetics for the target substance.
The absorption capacity of 3-acetamido-5-amino-4-hydroxybenzenesulphonic
acid is low (as has been stated section 5.4.1 of the dossier), which is
also supported by the fact that the bioaccumulation factor for the
substance is much lower and so even after the exposure the absorption
capability will be less in this case.
In case the substance, 3-acetamido-5-amino-4-hydroxybenzenesulphonic
acid, is absorbed (though in small quantity) it will not be accumulated
in the body. This is supported by the fact that the substance have not
only low BCF value (as mentioned in section 5.3.1 of the same dossier)
but also have a moderate level of Kow which will support the reasoning
that though the substance will enter the body but will get distributed
through the lipid in the body.
Further to this distribution after the absorption process, the excretion
process through urine would be faster as the molecular weight of the
substance, 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid, is > 300
and this is a favourable value for excretion via the urine route.
Dermal Absorption relation :
According to Danish QSAR study dermal
absorption value of 3-acetamido-5-amino-4-hydroxybenzenesulphonic
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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