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EC number: 254-879-2
CAS number: 40306-75-0
to Danish QSAR study dermal absorption value of
3-acetamido-5-amino-4-hydroxybenzenesulphonic acid is estimated to be
0.00001 mg/cm2/event (VERY LOW). Thus in case the
substance,3-acetamido-5-amino-4-hydroxybenzenesulphonic acid, is
absorbed (though in small quantity) it will not be accumulated in the
body. This is supported by the fact that the substance have not only low
BCF value but also have a moderate level of Kow which will support the
reasoning that though the substance will enter the body but will get
distributed through the lipid in the body.
dermal toxicity of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid
has not been observed for any of the exposure route of oral, dermal and
inhalation and so
the substance will not be considered for classification as per the C&L
substance will not be considered for classification in any of the
irritation activity as the end point data indicates that
3-acetamido-5-amino-4-hydroxy benzene sulphonic acid is non irritating
the QSAR prediction, the test material,
3-acetamido-5-amino-4-hydroxybenzenesulphonic acid, was estimated to be
non sensitizing to skin of human and so will not be considered for
classification as per the C&L regulation.
acid does not have any acute toxicity to any of the route of exposure
that is inhalation, dermal and oral route. Moreover do not show
irritation effect to skin and eye, is neither genotoxic and is nor
developmental or reproductive toxin.
absence of local effects following short-term or long-term exposure, no
dose-response data are available and a quantitative dose descriptor is
not derived. DNEL values for local exposure are therefore not calculated.
absence of acute systemic toxicity, no dose-response data are available
and a quantitative dose descriptor is not derived. DNEL values for acute
systemic effects are therefore not calculated.
approach to deriving DNEL values would be to use the repeated dose
toxicity dataset and apply assessment factors as described in ECHA
guidance documents. The critical endpoint is considered to be the LOEL of895.4425mg/kg/
bw in oral category.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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