Registration Dossier
Registration Dossier
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EC number: 200-087-7 | CAS number: 51-28-5
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data has been obtained from secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 995
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
- Principles of method if other than guideline:
- Method has not been specified. The study is considered reasonably well conducted.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dinitrophenol
- EC Number:
- 200-087-7
- EC Name:
- 2,4-dinitrophenol
- Cas Number:
- 51-28-5
- Molecular formula:
- C6H4N2O5
- IUPAC Name:
- 2,4-dinitrophenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 4 weeks
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 59 mg/kg diet
- Sex:
- not specified
- Remarks on result:
- other: no further information available
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No mortality LD0 was observed at dose <= 59 mg/Kg/day. A NOAEL of 59 mg/kg/day was determinated because food consumption and body weight gain in rats exposed to that dose of 2,4 -dinitrophenol in the diet for 4 weeks were similar to those of controls.
Applicant's summary and conclusion
- Conclusions:
- LD0 was observed at dose <= 59 mg/Kg/day.
A NOAEL of 59 mg/kg/day was observed for food consumption and body weight gain. - Executive summary:
Data has been obtained from secondary source that mentions Kaiser JA. 1964. Studies on the toxicity of diisophenol (2,6-diiodo-4-nitrophenol) to dogs and rodents plus some comparison with 2,4-dinitrophenol. Toxicol Appl Pharmacol 6:232-244.
Weanling rats were exposed to 2,4 -dinitrophenol in the feed for 4 weeks. No mortality LD0 was observed at dose <= 59 mg/Kg/day. A NOAEL of 59 mg/kg/day was determined because food consumption and body weight gain in rats exposed to that dose of 2,4 -dinitrophenol in the diet for 4 weeks were similar to those of controls.
Method has not been specified but the study is considered reasonably well conducted.
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