Registration Dossier
Registration Dossier
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EC number: 200-087-7 | CAS number: 51-28-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data have been obtained from secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 995
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 948
Materials and methods
- Principles of method if other than guideline:
- Application by bandage on abdomen. Further details of the test have not been specified.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dinitrophenol
- EC Number:
- 200-087-7
- EC Name:
- 2,4-dinitrophenol
- Cas Number:
- 51-28-5
- Molecular formula:
- C6H4N2O5
- IUPAC Name:
- 2,4-dinitrophenol
- Test material form:
- other: solution
- Details on test material:
- Composition of test material, percentage of components: solution of 3% of 2,4-dinitrophenol and 95% ethanol.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- other: bandage
- Preparation of test site:
- shaved
Results and discussion
In vivo
Results
- Remarks on result:
- other: see results below
Any other information on results incl. tables
The result of the test indicates a very slight irritation, including mild hyperemia, edema and exfoliation.
Applicant's summary and conclusion
- Interpretation of results:
- other: very slight irritation
- Remarks:
- Criteria used for interpretation of results: other: criteria used to assess not reported.
- Conclusions:
- 2,4-dinitrophenol is very slight irritant.
- Executive summary:
All information has been obtained from secondary source, that mentions Spencer HC, Rowe VK, Irish DD. 1948. Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture. J Ind Hyg Toxicol 30:10-25.
Solution of 3% of 2,4-dinitrophenol and 95% ethanol was applied through a bandage on rabbit shaved abdomen.
The result indicates that 2,4-dinitrophenol is a very slight irritant, including effects of mild hyperemia, edema and exfoliation, but in the study criteria of assessment it hasn't been reported.
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