Registration Dossier
Registration Dossier
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EC number: 200-087-7 | CAS number: 51-28-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data have been obtained from secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 995
- Reference Type:
- review article or handbook
- Title:
- Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture.
- Author:
- Spencer HC, Rowe VK, Irish DD.
- Year:
- 1 948
- Bibliographic source:
- J Ind Hyg Toxicol 30:10-25, 1948
Materials and methods
- Principles of method if other than guideline:
- Guinea pigs were exposed dermally to 100-1,000 mg/kg 2,4-dinitrophenol for 4 hours.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dinitrophenol
- EC Number:
- 200-087-7
- EC Name:
- 2,4-dinitrophenol
- Cas Number:
- 51-28-5
- Molecular formula:
- C6H4N2O5
- IUPAC Name:
- 2,4-dinitrophenol
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Duration of exposure:
- 4 hours
- Doses:
- To 100-1000 mg/kg of 2,4-dinitrophenol
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- ca. 100 - 200 other: mg/kg
- Sex:
- not specified
- Dose descriptor:
- other: LD20
- Effect level:
- 300 other: mg/kg
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 700 other: mg/kg
- Sex:
- not specified
- Dose descriptor:
- other: LOAEL
- Effect level:
- 300 other: mg/kg
Any other information on results incl. tables
No mortality was observed at 100 -200 mg/kg.
The lowest dose causing mortality LD20 was 300 mg/kg (20 %)
The lowest dose causing totally the mortality LD100 was 700 mg/kg (100%).
Due to the local effect it might be possible to identify a LOAEL of 300 mg/kg.
Applicant's summary and conclusion
- Conclusions:
- No mortality was observed at 100 or 200 mg/kg. LD20 was 300 mg/kg (20% mortallity ), and the lowest dose causing 100% mortality was 700 mg/kg.
Due to the local effect it might be possible to identify a LOAEL of 300 mg/kg. - Executive summary:
Data have been obtained from secondary source tha mentions Spencer HC, Rowe VK, Irish DD. 1948. Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture. J Ind Hyg Toxicol 30:10-25.Guinea pigs were exposed dermally to 100-1,000 mg/kg 2,4-DNP for 4 hours. No mortality was observed at 100 or 200 mg/kg. The lowest dose causing mortality at 20% was 300 mg/kg, and the lowest dose causing 100% mortality was 700 mg/kg. Due to the local effect it might be possible to identify a LOAEL of 300 mg/kg.
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