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EC number: 237-438-9
CAS number: 13784-51-5
request of Elf Atochem, Milano, Italia, the acute TOXICITY of the test
K3, by dermal route was evaluated in rats according to O.E.C.D. (No.
402, 24th February
1987) and E.C. (92/69/E.E.C.). The study was conducted in compliance
of Good Laboratory Practice.
test substance was administered by dermal route to a group of 10
Sprague-Dawley rats (5
males and 5 females). The test substance in its original form was
applied directly to the skin of the animals at a dose of 2000 mg/kg,
taking into consideration that the specific gravity (SG) of the test
substance was 1.025. After
24 hours under a semi-occlusive dressing, no residual test substance was
observed on removal of the dressing. The animals were checked for
clinical signs, mortality and body weight gain for a period of 14 days
following the single application of the test substance. A
necropsy was performed on each animal killed at the end of the study.
general behaviour and body weight gain of the animals were not affected
by treatment with the
test substance. No cutaneous reactions were observed. No deaths occurred
at 2000 mg/kg. A
macroscopic examination revealed no abnormalities in the animals killed
at the end of the study.
the experimental conditions, the LD50 of the test substance, PEROXIMON
K3, when administered
by dermal route in rats was higher than or equal to 2000 mg/kg.
No signs of toxicity
were observed at this dose.
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