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EC number: 237-438-9
CAS number: 13784-51-5
Ten male albino Charles River rats, weighing from 264 to 296 grams, were
used in this study. The test compound, SN4-l38-38, was administered as
an aerosol mist at a calculated atmospheric concentration of 13.1
mg./liter of air. During the l-hour exposure all animals were observed
continuously for changes in behavior and appearance. Following the
exposure, the animals were examined closely for pharmacodynamic and/or
toxic signs. After 9 days of observations, and body weight measurements
on days 7 and 9, animals were necropsied.
Exposure of rats for one continuous hour to an atmospheric concentration
of a mist of the test agent (13.1 mg./liter of air) failed to cause
adverse pharmacotoxic signs, mortality, or gross evidence of damage at
necropsy 9 days after exposure. Based on the results of this study, it
was concluded that the results indicate that the test compound does not
present a hazard to rats when a saturated atmosphere is inhaled over a
continuous period of one hour. The report also concluded that dependent
upon the use of this agent, there does not appear to be a hazard to man
by the route of inhalation provided ordinary care is exercised in the
handling of this material.
Only one concentration of the test item was tested and for an hour.
These approaches differ from the currently acceptable test guidelines.
Therefore the experimental value cannot be used for DNEL derivation.
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