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EC number: 237-438-9
CAS number: 13784-51-5
The following ECx(immobilization) values based on the fresh measured concentration were calculated by Probit analysis using max. likelihood regression at 21 days:
Concentration (mg ai/L)
95% confidence limits
Not determined due to nature of the data
Not determined due to the nature of the data
NOEC = No Observed Effect Concentration
LOEC = Lowest Observed Effect Concentration
14.98 – 15.00
4.30 – 4.31
18.99 – 19.00
5.5 – 5.6
NOEC No Observed Effect Concentration
LOEC Lowest Observed Effect Concentration
The following validation criteria were achieved during the test:
Mean number of live young per surviving adult (control group)
≥ 60 after 21 days
Coefficient of variation for control group*
No ephippia produced
>3 mg O2/L
≥ 7.7mg O2/L
pH (control group)
6 to 9Variation ≤ 1.5
7.3 to 8.20.9
* Based on total number of living offspring per parent animal alive at the end of the test
Number of live Young produced per adult by day 21
Mean Measured FreshConcentration (mg/L)
Mean Measured FreshConcentration(mg/L)
Number of Live YoungProduced per Adult byDay 21
At the start and throughout the test all control and test solutions were observed to be clear colorless solutions.
A study was performed to assess the chronic toxicity of the test
item to Daphnia magna. The method followed was designed to be
compatible with the OECD Guidelines for Testing of Chemicals (2012) No
211, "Daphnia magna Reproduction Test" referenced as Method
C.20 of Commission Regulation (EC) No. 440/2008.
Based on the results of a preliminary range‑finding test and an
initial experiment, Daphnia magna were exposed (10 replicates of
a single daphnid per group) to solutions of the test item at nominal
concentrations of 6.25, 12.5, 25, 50 and 100 mg/L for a period of
The numbers of live and dead adult daphnia and young daphnids
(live and dead) were determined daily. The daphnia were fed daily with a
mixture of algal suspension and Tetramin®flake food
Analysis of the fresh test preparations on Days 0, 5, 12 and 20
showed measured test concentrations to range from 3.1 to 42 mg/L
(equivalent to 0.93 to 12 mg active ingredient (ai/)L). An increase in
the measured concentration of the aged test preparations on Days 1, 6,
13 and 21 was observed to between 3.4 and 57 mg/L (equivalent to 1.0 to
17 mg ai/L). Inspection of the data could show no reason for the
increase observed and hence it was considered appropriate to calculate
the results based on the average measured concentration of the freshly
Exposure of Daphnia magna to the test item gave the
following results based on the average measured concentration of the
freshly prepared media:
No Observed Effect Concentration
Lowest Observed Effect Concentration
The 21 Day EC50 and EC10 (immobilization)
value, based on the average measured concentration of the freshly
prepared test preparations, for the parental daphnia generation (P1)
were calculated to be 13 mg/L and 5.6 mg/L, respectively (equivalent to
3.9 mg a.i./L and 1.7 mg a.i./L).
The 21 Day EC50 and EC10 (reproduction)
based on the average measured concentration of the freshly prepared test
preparations were 19 mg/L and 15 mg/L, respectively (equivalent to 5.6
mg a.i./L and 4.3 mg a.i./L).
The NOEC and the LOEC based on the average
measured concentration of the freshly prepared test preparations were 14
and 24 mg/L, respectively (equivalent to 4.0 and 7.1 mg a.i./L).
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