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EC number: 446-620-9 | CAS number: 120983-72-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2
- Temp.:
- 25 °C
- pH:
- 6.8
- Remarks on result:
- other: mean value from 3 single values
- Remarks:
- Retention time (min): 2.799
- Details on results:
- In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C. The reference Paw-values in the OECD guideline presumably refer to 25 °C. Even though the column temperature was 40 °C, this temperature has no influence on the result of the determination. Therefore the Pow-value of the test item determined within this study also refers to 25 °C.
- Conclusions:
- The partition coefficient (logPow) of 2.0 was determined at 25 °C and pH 6.8.
- Executive summary:
The partition coefficient was determined by the HPLC-method according to OECD TG 117. The partition coefficient (Pow) was determined according to the HPLC method at 40 °C. In order to comply with the guideline OECD 117 and considering environmental relevance, buffered water at pH 6.8 was chosen. The reference Pow-values in the OE CD-guideline presumably refer to 25 °C. Even though the column temperature was 40 °C, this temperature is without influence on the result of the determination. The calibration was done referring to Pow- values of reference substances determined at 25 °C. For the determination of the partition coefficient (Koc) six calibration standards with log Koc from 1.0 -3.0 were established. The partition coefficient (logPow) of 2.0 was determined at 25 °C and pH 6.8. All validity criteria have been met.
Reference
Description of key information
The partition coefficient (logPow) of 2.0 was determined at 25 °C and pH 6.8.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2
- at the temperature of:
- 25 °C
Additional information
In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C. The reference Paw-values in the OECD guideline presumably refer to 25 °C. Even though the column temperature was 40 °C, this temperature has no influence on the result of the determination. Therefore the Pow -value of the test item determined within this study also refers to 25 °C.
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