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EC number: 446-620-9 | CAS number: 120983-72-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Auto flammability
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- Stability in organic solvents and identity of relevant degradation products
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- Stability: thermal, sunlight, metals
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
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- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 3 - 17, 2000
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 1992
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 446-620-9
- EC Name:
- -
- Cas Number:
- 120983-72-4
- Molecular formula:
- Hill formula: C5H6Cl2O CAS formula: C5H6Cl20
- IUPAC Name:
- 2-chloro-1-(1-chlorocyclopropyl)ethan-1-one
- Test material form:
- liquid
- Details on test material:
- purity: 92.3 %
Constituent 1
- Specific details on test material used for the study:
- purity 92.11%
no prior stability testing
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- other: None
- Amount / concentration applied:
- 0.5 ml/ patch
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 3
- Details on study design:
- Approximately 24 hours before the test, the fur was removed by shaving from the dorsal area of the trunk of the animals. Care was taken to avoid abrading the skin. Only animals with healthy intact skin were used. A dose of 0.5 ml was applied to the test site (area: approx. 6 cm2). The test substance was applied to the test site and then covered with a gauze patch. The patch was held in contact with the skin by means of a semi-occlusive dressing for the duration of the exposure period. The surrounding untreated skin served as a control. Exposure time was four hours. During the exposure the animals were kept in comfortable restrainers.
Examination of the skin: the skin sites were evaluated immediately before the application of the test substance. After the 4-hour exposure period the patch was removed and the skin sites were evaluated. Scores were taken 60 minutes, 24, 48, 72 hours and 4 - 1 4 days after patch removal. The evaluation of the skin irritation was based on the grading given in the Appendix 1 to this report. Based on most recent guidelines the skin reactions are monitored until the changes observed have completely subsided, however for not more than 14 days after application. Animals that do not reveal any lesions anymore for 24 hours following the first 72 hours of observation are sacrificed.
General criteria: body weight of all animals was measured at the beginning of the study.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14d
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes not fully reversible within 14 days
- Other effects:
- An erythema (grade2) was observed in all animals 1 and 24
hours after patch removal, the test site was pale and
indurated with an approx. 2 cm wide dark-red-brown necrotic
strip around the test site from 48 hours until 14 days after
patch removal (skin destruction).
An oedema (grade 1) was observed in all animals 1 and 24
hours after patch removal and an oedema (grade 2) from 48
hours until 14 days after patch removal.
There were no systemic intolerance reactions.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Based on irreversible findings (skin destruction from 48h until 14d) test compound is corrosive; since since a single exposure period of 4h was investigated no sub-categorization can be applied.
- Executive summary:
Under the present test conditions the three rabbits exposed for 4 hours to 0.5 ml JAU 6476-Chloromethylketone/patch and animal (semi-occlusive condition) showed the following effects: An erythema (grade 2) was observed in all animals 1 and 24 hours after patch removal, the test site was pale and indurated with an approx. 2 cm wide dark-red - brown necrotic strip around the test site from 48 hours until 14 days after patch removal (skin destruction). An oedema (grade 1) was observed in all animals 1 and 24 hours after patch removal and an oedema (grade 2) from 48 hours until 14 days after patch removal. There were no systemic intolerance reactions.
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