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EC number: 420-380-5 | CAS number: 136465-81-1
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Modern study peformed under GLP and using the recommended method, EU method A.4.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Type of method:
- gas saturation method
Test material
- Reference substance name:
- PTH-decahydroamide
- IUPAC Name:
- PTH-decahydroamide
- Reference substance name:
- Ro 31-9373/000
- IUPAC Name:
- Ro 31-9373/000
- Details on test material:
- The test material received from F. Hoffmann-La Roche Ltd was a white solid powder from lot no. 25927 with a purity of 99.8%.
Constituent 1
Constituent 2
Results and discussion
Vapour pressureopen allclose all
- Temp.:
- 25 °C
- Vapour pressure:
- 0.001 Pa
- Temp.:
- 35 °C
- Vapour pressure:
- 0.004 Pa
- Temp.:
- 40 °C
- Vapour pressure:
- 0.01 Pa
Any other information on results incl. tables
The test was carried out at 25 ⁰C and 35 ⁰C in four replicates for each temperature at a flow rate of 10 mL/min. During the preliminary test the vapour pressure was determined at four flow rates at 40 ⁰C. The results are presented in the table below;
Temp (⁰C) |
Replicate |
Flow Rate (mL/min) |
Duration (h) |
Gas Volume (m3) |
Mass PTH-decahydroamide (g x 10-6) |
Vapour Pressure (Pa) |
25 |
1 |
10 |
116 |
0.0696 |
9.929 |
1.482 x 10-3 |
25 |
2 |
10 |
116 |
0.0696 |
10.380 |
1.550 x 10-3 |
25 |
3 |
10 |
116 |
0.0696 |
11.226 |
1.676 x 10-3 |
25 |
4 |
10 |
116 |
0.0696 |
7.798 |
1.165 x 10-3 |
|
|
|
|
|
Average |
1.468 x 10-3 |
35 |
1 |
10 |
54 |
0.0324 |
11.665 |
3.868 x 10-3 |
35 |
2 |
10 |
54 |
0.0324 |
12.403 |
4.113 x 10-3 |
35 |
3 |
10 |
54 |
0.0324 |
11.867 |
3.935 x 10-3 |
35 |
4 |
10 |
54 |
0.0324 |
11.642 |
3.860 x 10-3 |
|
|
|
|
|
Average |
3.944 x 10-3 |
40 |
1 |
5 |
- |
0.151 |
171.755 |
12.402 x 10-3 |
40 |
2 |
10 |
- |
0.302 |
301.545 |
10.886 x 10-3 |
40 |
3 |
20 |
- |
0.605 |
382.855 |
6.911 x 10-3 |
40 |
4 |
25 |
- |
0.756 |
636.380 |
9.190 x 10-3 |
|
|
|
|
|
Average |
9.847 x 10-3 |
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of PTH-decahydroamide (Ro 31 -9373/000) was determined to be 1.468 x 10(-3) Pa at 25 ⁰C,
3.944 x 10(-3) Pa at 35 ⁰C and 9.847 x 10(-3) Pa at 40 ⁰C. - Executive summary:
The vapour pressure of PTH-decahydroamide (Ro 31 -9373/000) was determined using EC directive 92/69/EEC, A.4 (1992).
The vapour pressure of PTH-decahydroamide (Ro 31 -9373/000) was determined to be 1.468 x 10-3Pa at 25 ⁰C,
3.944 x 10-3Pa at 35 ⁰C and 9.847 x 10-3Pa at 40 ⁰C.
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