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EC number: 420-380-5 | CAS number: 136465-81-1
No further information on results to report.
The acute oral toxicity of Ro 31-9373/000 (PTH-Decahydroamide) was investigated in rats. The study objective was to determine the maximum non-lethal oral dose and to this end dose levels of 200, 1000 and 2000 mg/kg bw were administered to groups of rats. Two animals died following dosing at 2000 mg/kg bw and one rat died after 1000 mg/kg bw administration. Clinical signs noted ante-mortem included convulsions and collapse. No necropsy changes of toxicological significance were observed in the decedents. Clinical signs observed in the surviving rats included piloerection, ataxia and subdued behaviour. No necropsy findings were reported for the rats terminated on Day 15.
The maximum non-lethal dose was found to be between 200 and 1000 mg/kg bw following single oral administration of Ro 31 -9373/000 (PTH-Decahydroamide) to rats.
The median lethal dose (LD50) may exceed 2000 mg/kg bw but confirmation of the number of rats exposed, compared to number of mortalities is required, this information was not available in the summary of the study findings.
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