Registration Dossier

Administrative data

Endpoint:
surface tension
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Modern study peformed under GLP and using the recommended method, EC directive 92/69/EEC, A.5.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.5 (Surface Tension)
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes
Type of method:
ring method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
The test material received from F. Hoffmann-La Roche Ltd was a white solid powder from lot no. 25927 with a purity of 99.8%.

Results and discussion

Surface tension
Surface tension:
51.9 mN/m
Temp.:
20 °C
Conc.:
1 g/L

Any other information on results incl. tables

The gauging factor (C) was determined to be 1.01. Four consecutive measurements were performed on the 1.0 g/L solution of PTH-Decahydroamide and the gauging factor applied to get the corrected surface tension. A constant value of 51.9 mN/m at 20 °C was determined for the corrected surface tension.

Equilibration Time at 20 ⁰C (minutes)

Measured Surface Tension (mN/m)

Corrected Surface Tension (mN/m)

10

52.65

51.9

15

52.65

51.9

25

52.65

51.9

40

52.65

51.9

Average

51.9

Std. Dev.

0.0 (n=4)

Based on the criteria as outlined in the EC guideline A.5, it is concluded that PTH-decahydroamide (Ro 319373/000) should be regarded as a surface active material.

Applicant's summary and conclusion

Conclusions:
The surface tension of a 1 g/L solution of PTH-decahydroamide (Ro 31 -9373/000) was determined to be 51.9 mN/m. Based on the criteria as outlined in the EC guideline A.5, it was concluded that PTH-decahydroamide (Ro 319373/000) should be regarded as a surface active material.
Executive summary:

The determination of the surface tension of an aqueous solution of PTH-decahydroamide (Ro 31 -9373/000) was performed using EC directive 92/69/EEC, A.5 (1992).

The surface tension of a 1 g/L solution of PTH-decahydroamide (Ro 31 -9373/000) was determined to be 51.9 mN/m. Based on the criteria as outlined in the EC guideline A.5, it was concluded that PTH-decahydroamid (Ro 319373/000) should be regarded as a surface active material.

This conclusion is in agreement with the foaming phenomenon observed when PTH-decahydroamide (Ro 31 -9373/000) is strongly agitated in aquoeus solutions.