Registration Dossier
Registration Dossier
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Profile for Fuel Oils
- Author:
- ATSDR
- Year:
- 1 995
- Bibliographic source:
- ATSDR (1995) Toxicological Profile for Fuel Oils June 1995.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Inhalation Exposure (Peer reviewed data summary)
- Principles of method if other than guideline:
- Inhalation Exposure (Peer reviewed data summary)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- diesel fuels of different grades
- IUPAC Name:
- diesel fuels of different grades
- Details on test material:
- Test substance & concentration: home heating oil no. 2 (400 ppm), fuel oil UNSP (408.8 ppm), or diesel fuel vapor (401.5 ppm)
Constituent 1
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Study results:
No developmental effects (soft tissue changes, skeletal abnormalities, inhibition of fetal growth) were noted in the fetuses of female rats exposed to various sorts of Fuel Oils.Applicant's summary and conclusion
- Conclusions:
- Diesel Fuel did not induce damage to reproductive organs/ tissues of experimental animals when was tested via inhalation or dermal exposure routes. In addition, no fetuces abnormalities were seen in a few inhalation studies in rodents.
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