Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- Depressant effects associated with the inhalation of uncombusted diesel vapor.
- Author:
- Kainz & White
- Year:
- 1 984
- Bibliographic source:
- In: MacFarland et al., eds. Advances in modern environmental toxicology. Volume VI: Applied toxicology of petroleum hydrocarbons. Princeton, NJ: Princeton Scientific Publishers, Inc.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Subacute Inhalation exposure
- Principles of method if other than guideline:
- Subacute Inhalation exposure
- GLP compliance:
- not specified
Test material
- Reference substance name:
- diesel fuel no. 2 vapor
- IUPAC Name:
- diesel fuel no. 2 vapor
- Details on test material:
- diesel fuel no. 2 vapor
Constituent 1
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Study results:
Mortality:
At 204 mg/m3: 3 of 10 mice died;
At up to 135 mg/m3: no mortality observed.
Toxicity effects:
At 65 mg/m3 -mild transient ataxia and disturbed gait in mice.
At ≥135 mg/m3 –neurological effects, completely reversible within 24 hours of cessation of exposure.
At ≥135 mg/m3 –vasodilation in the ear and tail veins.
At 204 mg/m3 -decreased food and water intake with subsequent weight loss and dehydration.
LOEC (short-term, inhalation, mice) =65 mg/m3 (mild transient neurological effects)
Applicant's summary and conclusion
- Conclusions:
- LOEC (short-term, inhalation, mice) =65 mg/m3 (mild transient neurological effects)
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