Registration Dossier
Registration Dossier
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- National toxicology program technical report series no. 310: Toxicology and carcinogenesis studies of marine diesel fuel and JP-5 navy fuel in B6C3Fl mice (dermal studies).
- Author:
- NTP
- Year:
- 1 986
- Bibliographic source:
- Research Triangle Park, NC: National Toxicology Program/ National Institutes of Health. NIH publication no. 86-2566.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- diesel fuel
- IUPAC Name:
- diesel fuel
- Details on test material:
- Test Substance: mixtures of petroleum-derived products: marine diesel fuel (mixture of hydrocarbons containing 12.7% paraffins, 43.7% naphthalenes, and 43.6% aromatic compounds) and JP-5 jet aviation fuel (mixture of hydrocarbons containing 52.8% cycloparaffins, 30.8% paraffins, 15.9% aromatics, and 0.5% olefins)
Constituent 1
Results and discussion
Any other information on results incl. tables
Study observed:
Marine diesel fuel: not mutagenic in Salmonella typhimurim strains TA98, TA100, TA1535, or TA1537 in the presence or absence of Aroclor 1254-induced male Sprague-Dawley rat or male Syrian hamster S9 when tested according to the preincubation protocol.
JP-5 navy fuel: not mutagenic in strains TA97, TA98, TA100, or TA1535 in the presence or absence of Aroclor 1254-induced male Sprague-Dawley rat or male Syrian hamster S9 when tested according to the preincubation protocol.
Applicant's summary and conclusion
- Conclusions:
- not mutagenic in this study
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