Registration Dossier
Registration Dossier
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- National toxicology program technical report series no. 310: Toxicology and carcinogenesis studies of marine diesel fuel and JP-5 navy fuel in B6C3Fl mice (dermal studies).
- Author:
- NTP
- Year:
- 1 986
- Bibliographic source:
- Research Triangle Park, NC: National Toxicology Program/ National Institutes of Health. NIH publication no. 86-2566.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- other: Acute Dermal exposure (Single application)
Test material
- Reference substance name:
- marine diesel fuel
- IUPAC Name:
- marine diesel fuel
- Details on test material:
- marine diesel fuel (mixture of hydrocarbons containing 12.7% paraffins, 43.7% naphthalenes, and 43.6% aromatic compounds)
Constituent 1
Results and discussion
Any other information on results incl. tables
Study results:
No mortalities were observed.
No substance-related signs of toxicity were observed
LD50 (dermal, mice) > 40000 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- Diesel Fuel products did not cause any mortality or clinical signs of toxicity when tested in mice via skin exposure at single doses of up to 40000 mg/kg bw. From the data on toxicokinetics, long carbon chain aliphatic hydrocarbons of petroleum origin have only limited absorption, including dermal exposure. Therefore, it is considered that Diese Fuel is of low acute toxicity by dermal exposure route.
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