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EC number: 258-436-4 | CAS number: 53220-22-7
In an acute oral toxicity study according to OECD TG 401 the LD50 value was determined to be above 2000 mg/kg bw.
The acute oral toxicity of ditetradecyl peroxydicarbonate was investigated in a group of five male and five female CD rats at a dosage of 2000 mg/kg according to OECD guideline 401 and EU method B.1. The animals were starved overnight prior to dosing and the test material was administered at a constant volume-dosage of 20 mL/kg in aqueous 0.5 % w/v methylcellulose.
Mortality and sings of reaction to treatment were recorded during a subsequent 14 -day observation period. The animals were killed on the following day and subjected to necropsy.
There was no death. Signs of reaction to treatment were confined to piloerection in all animals on the day of dosing. The animals were overtly normal on the following day. The animals achieved expected bodyweight gains and necropsy revealed no significant macroscopic lesion. The acute oral median lethal dosage (LD50) of the test material was greater than 2000 mg/kg.
The acute oral toxicity of ditetradecyl peroxydicarbonate was investigated in a group of five male and five female CD rats at a dosage of 2000 mg/kg according to OECD guideline 401 and EU method B.1; the test material was administered at a constant volume-dosage of 20 mL/kg in aqueous 0.5 % w/v methylcellulose. Mortality and sings of reaction to treatment were recorded during a subsequent 14 -day observation period. Besides piloerection in all animals on the day of dosing, all animals were overtly normal on the following day; none died; necropsy revealed no significant macroscopic lesion.
The LD50 value is determined to be > 2000 mg/kg bw.
No acute inhalation study with the test substance is available.
Due to the solid properties of the test substance, exposure to vapour is considered negligible. In addition, experimental data on acute oral toxicity revealed no test substance related effects. Further, no skin and eye irritation potential was evaluated in the available in vivo studies and therefore no respiratory irritation is expected.
No acute dermal study with the test substance is available.
Numerous organic peroxides have been tested in acute dermal toxicity tests (41 organic peroxides covering all chemical subgroups/families of organic peroxides, excluding hydroperoxides). Experimental data of all of these organic peroxides, (except hydroperoxides), show no toxic effects at dermal application up to the tested concentration limit of 2000 mg/kg bw and show for this reason an acute dermal toxicity of >2000 mg/kg bw. Dermal peentration of the test item is further expected to be very low based on its physico-chemical properties. Therefore, a weight of evidence approach is scientifically applicable for chemically comparable organic peroxides and allows one to conclude also a dermal LD50 > 2000 mg/kg bw for the untested organic peroxide.
Based on the available data the test substance is not classified and labelled for acute oral, dermal and inhalation toxicity according to Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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