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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012-06-11 to 2012-06-12
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Version / remarks:
May 2008
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Version / remarks:
January 2001
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC estimation method
Media:
soil/sewage sludge
Radiolabelling:
no
Test temperature:
25 °C
Details on study design: HPLC method:
HPLC conditions:
- Column: LiChrospher 100 CN (5µm) 250x4, No: 933278
- Mobile Phase: methanol : water = 65 : 35 (v/v)
(pH value of ultrapure water: 6.5)
- Flow: 0.8 mL/min
- Injection volume: 5 µL
- Temperature: 25 °C
- Detector: UV 254 nm (Reference Items)
- Detector: UV 205 nm (Test Item)
Analytical monitoring:
no
Details on sampling:
Three series of the reference solutions were measured with two parallel injections, each. Three series of the test item solution were measured with two parallel injections, each. The retention times were determined. The three calibration series and three test item series were measured alternately.
Details on test conditions:
Test solutions:
The reference items were dissolved in acetonitrile. The concentrations of the stock solutions were about 1 mg/mL. These stock solutions were diluted with eluent resulting in concentrations of the test solutions of approximately 10 µg/mL. The sodium nitrate and DDT stock solutions were diluted with eluent resulting in concentration of the test solution of approximately 100 µg/mL. The test item was dissolved in acetonitrile. The concentration of this solution was about 2 mg/mL. It was diluted with acetonitrile to 1 mg/mL.
Key result
Type:
log Koc
Value:
> 5.63
Temp.:
25 °C
Details on results (HPLC method):
- Retention times (mean value) of reference substances used for calibration:
acetanilide (3.48 minutes), methyl benzoate (3.76 minutes), isoproturon (3.71 minutes), Linuron (3.92 minutes), fenthion (4.23 minutes), DDT (4.99 minutes)
- Details of fitted regression line (log k' vs. log Koc): log k = 0.055 * log Koc + 0.046 (Rsq = 0.984)
- Average retention data for test substance: 6.64 min

Retention time measured for ditetradecyl peroxydicarbonate (6.64 min) is higher than the retention time of the last eluting standard; DDT (4.99 min). This result shows that log Koc of ditetradecyl peroxydicarbonate is higher than the calibrated range. Using the HPLC method the log Koc of ditetradecyl peroxydicarbonate was determined to be > 5.63.

Quality criteria were met, as values of log Kocderived from individual measurements fell within a range of 0.25 log units. The correlation coefficient R for the relationship between log k and log Kocof the reference item is 0.984. The difference of the estimated adsorption coefficient to the value of reference item fell within a range of ± 0.5 log units.

Validity criteria fulfilled:
yes
Conclusions:
Using the HPLC method the log Koc (at 25 °C) of ditetradecyl peroxydicarbonate was determined to be > 5.63.
Executive summary:

The adsorption coefficient (Koc) on soil and sewage sludge of ditetradecyl peroxydicarbonate was assessed according to EU menthod C.19 and OECD guideline no. 121 using the HPLC method. As the retention time measured for ditetradecyl peroxydicarbonate (6.64 min) is higher than the retention time of the last eluting standard; DDT (4.99 min), the log Koc (at 25 °C) of ditetradecyl peroxydicarbonate was determined to be > 5.63.

Description of key information

Using the HPLC method the log Koc (at 25 °C) of ditetradecyl peroxydicarbonate was determined to be > 5.63.

Key value for chemical safety assessment

Additional information

The adsorption coefficient (Koc) on soil and sewage sludge of ditetradecyl peroxydicarbonate was assessed according to EU menthod C.19 and OECD guideline no. 121 using the HPLC method. As the retention time measured for ditetradecyl peroxydicarbonate (6.64 min) is higher than the retention time of the last eluting standard; DDT (4.99 min), the log Koc (at 25 °C) of ditetradecyl peroxydicarbonate was determined to be > 5.63.