Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Test material information:
Composition 1
Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

A waiver is proposed for this endpoint as sodium hydrogen difluoride is corrosive. There are no animal data which suggest that bifluorides, HF or fluorides are skin sensitisers; the local effects of sodium hydrogen difluoride exposure will be dominated by irritation/corrosion. Similarly there is no evidence of skin sensitisation from occupational exposure reports of delayed dermal effects in some accidental exposures cases are due to irritancy rather than sensitisation.


Migrated from Short description of key information:
A waiver is proposed for this endpoint as sodium hydrogen difluoride is corrosive.

Justification for selection of skin sensitisation endpoint:
In accordance with Column 2 of the Annex VIII REACH data requirements (specific rules for adaptation from Column 1), a study does not need to be conducted because the substance is classified as corrosive.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

There is currently no recognised test guideline for respiratory sensitisation. The local effects of sodium hydrogen difluoride exposure will be dominated by irritation/corrosion. Similarly there is no evidence of respiratory sensitisation (asthma) from occupational exposure.


Migrated from Short description of key information:
No data are available.

Justification for classification or non-classification

No classification is proposed in the absence of any indication that sodium hydrogen difluoride can cause sensitisation.