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EC number: 222-321-7
CAS number: 3425-61-4
All acute toxicity test were not
performed with Tert-amyl hydroperoxide, however, missing data are
available by Read-Across with the analogue substance
The acute toxicity test to Daphnia
magna was not performed with Tert-amyl hydroperoxide, but through
analogy with 1,1,3,3-Tetramethylbutyl hydroperoxide, the data obtained
is considered for the registered substance: an acute toxicity test to Daphnia
magna was conducted in accordance with OECD test guidelines and with
the OECD Principles of Good Laboratory Practice. The toxicity of the
test chemical and any formed degradation products to juvenile daphnia
was determined in a static system over an exposure period of 48 hours:
the NOEC was determined as 4.21 mg/L (Measured Mean Concentration) ;the
EC50 (48h) was calculated as 6.7 mg/l. (Measured Mean).
Regarding toxicity to algae, 2 studies
are available. The first one was performed with the registered substance
and the second, which is used as supporting study, with the analogue
substance 1,1,3,3-Tetramethylbutyl hydro peroxide.
The determination of the growth
inhibition of the freshwater algae Pseudokirchneriella
subcapitata exposed to the test item TERT-AMYL PEROXIDE for
duration of 72 hours was assessed according to the OECD Guideline 201 in
a GLP study. The results were as follows (extrapolated concentrations as
geometric mean between measured initial and final abiotic values):
ErC50-72h = 1.2 mg/L
ErC10-72h = 0.38 mg/L
In order to predict the effects of
1,1,3,3-Tetramethylbutyl hydro peroxide in an aquatic environment, an
Algal Growth Inhibition test was conducted in accordance with OECD test
guidelines and with the OECD Principles of Good Laboratory Practice.
The toxicity of the test chemical to
an exponentially growing culture of P. subcapitata was determined
in a sealed system over an exposure period of 72 hours: the ErC10(72h)
was calculated as 2.9 mg/L (Growth rate). The ErC50(72h) was calculated
as 5.6 mg/L. (Growth rate Geometric Measured Means).
These tests on algae indicate that
both substances are "Toxic" to algae.
There is no test performed with
Tert-amyl hydroperoxide to assess the toxic effects on microorganisms.
This data is read-across from data obtained with1,1,3,3-Tetramethylbutyl
The toxicity to activated sludge was
determined in accordance with OECD Test Guideline 209, and in compliance
with the OECD principles of Good Laboratory Practice: the EC50 of
1,1,3,3-tetramethylbutyl hydroperoxide for activated sludge after 3
hours contact time is 138 mg/L. The EC10 after 3 hours contact time is
Referring to the position paper "OP
Consortium PP_Acute to Chronic Ratio.pdf" (attached to IUCLID), it can
be conclude that algae and daphnids are the most sensitive species when
tested with organic peroxides. As a consequence, no test on fish have
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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