Registration Dossier
Registration Dossier
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EC number: 202-854-1 | CAS number: 100-46-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP defined. Cross reactivity with other substance investigated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Principles of method if other than guideline:
- Method: other: In a skin sensitisation study in 4 human volunteers, 1 % benzylamine in vaseline was applied to the back, covered with a plaster. The exposition time was 24 h and the reading took place after 24, 48 and 72 h post exposure. 4 Patients with allergic contact dermatitis due to m-Xylylene diamine revealed allergic cross reactions to benzylamine.
- GLP compliance:
- no
- Type of study:
- other: epicutaneous test
Test material
- Reference substance name:
- 100-46-7
- IUPAC Name:
- 100-46-7
- Details on test material:
- - Name of test material: Benzylamine
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: epicutaneous, covered with a plaster (no further information)
- Vehicle:
- no data
- Concentration / amount:
- no data
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- no data
- Concentration / amount:
- no data
- No. of animals per dose:
- 4 humans
Results and discussion
Any other information on results incl. tables
Four patients with allergic contact dermatitis due to m-Xylylene diamine revealed allergic cross reactions to benzylamine.
Applicant's summary and conclusion
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