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EC number: 202-854-1 | CAS number: 100-46-9
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
The toxicity of benzylamine (CAS 100-46-9) to microorganisms was investigated in a 40-h growth inhibition test with Tetrahymena pyriformis (Schultz, 1997) conducted to generally accepted scientific principles. Based on nominal test concentrations, a 40-h IC50 of 186 mg/L was determined; the study is acceptable for assessment and is selected as key data.
The key study is supported by two read-across studies on the structurally similar substance benzyldimethylamine (CAS 103-83-3). With this substance, a respiration inhibition test with activated sludge according to the OECD guideline 209 was conducted. As the EC20 after 30 min was determined at the highest test concentration of 575 mg/L, the EC50 is concluded to be beyond this concentration (BASF AG, 1987). However, the activated sludge in this study was taken from an industrial source instead of a domestic sewage treatment plant. In the second study with benzyldimethylamine (CAS 103-83-3), a growth inhibition test with Pseudomonas putida (according to Bringmann-Kuehn), an EC50 value was determined at 750 mg/l after 17 h.
In addition a supporting guideline study (OECD 209) was conducted with the structurally similar substance methylbenzylamine (CAS 3886-69-9). An EC20 value was determined at 550 mg/L after 30-min, the EC50 was beyond the highest test concentration of 1000 mg/L (BASF AG, 1998). All validity criteria were fulfilled; the activated sludge was taken from a domestic source.
Based on the available data, toxic effects on microorganisms are not to be expected for benzylamine.
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