Registration Dossier
Registration Dossier
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EC number: 202-854-1 | CAS number: 100-46-9
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP defined. Cross reactivity with other substance investigated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Method: other: 1 % benzylamine in vaseline to the back, covered with a plaster, exposition time 24 h, reading 24, 48, 72 h post exposure
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzylamine
- EC Number:
- 202-854-1
- EC Name:
- Benzylamine
- Cas Number:
- 100-46-9
- Molecular formula:
- C7H9N
- IUPAC Name:
- 1-phenylmethanamine
- Details on test material:
- - Name of test material: Benzylamine
Constituent 1
Method
- Type of population:
- occupational
- Controls:
- no data
- Route of administration:
- dermal
Results and discussion
Any other information on results incl. tables
Method: other: 1 % benzylamine in vaseline to the back, covered with a plaster, exposition time 24 h, reading 24, 48, 72 h post exposure
Applicant's summary and conclusion
- Executive summary:
In a skin sensitisation study in 4 human volunteers, 1 % benzylamine in vaseline was applied to the back, covered with a plaster. The exposition time was 24 h and the reading took place after 24, 48 and 72 h post exposure. 4 Patients with allergic contact dermatitis due to m-Xylylene diamine revealed allergic cross reactions to benzylamine.
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